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Mga lathalain

Nuñez, JK, Chen, J., Pommier, GC, Cogan, JZ, Replogle, JM, Adriaens, C., Ramadoss, GN, Shi, Q., Hung, KL, Samelson, AJ, Pogson, AN, Kim, JYS , Chung, A., Leonetti, MD, Chang, HY, Kampmann, M., Bernstein, BE, Hovestadt, V., Gilbert, LA, Weissman, JS Genome-wide programmable transcriptional memory sa pamamagitan ng CRISPR-based epigenome editing. Cell 184 (2021).

 

Tian R., Samelson, AJ, Rezelj, VV, Chen, M., Ramadoss, GN, Guo, X., Kain, AM, Tran, QD, Lim, SA, Lui, I., Nuñez, JK, Rockwood, SJ , Liu, N., Carlson-Stevermer, J., Oki, J., Maures, T., Holden, K., Weissman, JS, Wells, JA, Conklin, B., Vignuzzi, M., Kampmann, M. Hinaharang ng inhibition ng BRD2 ang impeksyon ng SARS-CoV-2 in vitro sa pamamagitan ng pagbabawas ng transkripsyon ng host receptor na ACE2. bioRxiv (2021).

 

Chen, J., Brunner, A., Cogan, JZ, Nuñez, JK, Fields, AP, Adamson, B., Mann, M., Leonetti, MD, Weissman, JS Pervasive functional micropeptides sa mga tao na naka-encode ng non-canonical open pagbabasa ng mga frame. Science 367 (2020).

 

Tak, YE, Kleinstiver, BP, Nuñez, JK, Hsu, JY, Horng, JE, Gong, J., Weissman, JS, Joung, JK Inducible at multiplex na regulasyon ng gene gamit ang CRISPR–Cpf1-based transcription factor. Mga Paraan ng Kalikasan 14 (2017).

 

Adamson B., Norman, TM, Jost, M., Cho, MY, Nuñez, JK, Chen, Y., Villalta, JE, Gilbert, LA, Horlbeck, MA, Hein, MY, Pak, RA, Gray, AN, Gross, CA, Dixit, A., Parnas, O., Regev, A., Weissman, JS Ang isang multiplexed single-cell na CRISPR screening platform ay nagbibigay-daan sa systematic dissection ng unfolded protein response. Cell 167 (2016).

 

Nuñez, JK, Bai, L., Harrington, LB, Hinder, TL, Doudna, JA Ang CRISPR immunological memory ay nangangailangan ng host factor para sa pagiging tiyak. Molecular Cell 62 (2016).

 

Wright, AV, Nuñez, JK, Doudna, JA CRISPR systems: Nature's toolbox para sa genome engineering. Cell 164 (2016). Suriin ang artikulo.

 

Nuñez, JK, Harrington, LB, Doudna, JA Chemical at biophysical modulation ng Cas9 para sa tunable genome engineering. ACS Chemical Biology 11 (2016). Suriin ang artikulo.

 

Nuñez, JK*, Harrington, LB*, Kranzusch, PJ, Engelman, AN, Doudna, JA Foreign DNA capture sa panahon ng CRISPR–Cas adaptive immunity. Kalikasan 527 (2015b). *Pantay na kontribusyon.

 

Nuñez, JK, Lee, ASY, Engelman, AN, Doudna, JA Integrase-mediated spacer acquisition sa panahon ng CRISPR–Cas adaptive immunity. Kalikasan 519 (2015a).

 

Ang Nuñez, JK, Kranzusch, PJ, Noeske, J., Wright, AV, Davies, CW, Doudna, JA Cas1–Cas2 complex formation ay namamagitan sa pagkuha ng spacer sa panahon ng CRISPR–Cas adaptive immunity. Nature Structural & Molecular Biology 21 (2014).

 

Musselman, CA, Avvakumov, N., Watanabe, R., Abraham, CG, Lalonde, ME, Hong, Z., Allen, C., Roy, S., Nuñez, JK, Nickoloff, J., Kulesza, CA, Yasui, A., Côté, J., Kutateladze, TG Molecular na batayan para sa H3K36me3 na pagkilala ng Tudor domain ng PHF1. Nature Structural & Molecular Biology 19 (2012).